Transcription factor functionality and transcription regulatory networks
نویسندگان
چکیده
منابع مشابه
Transcription factor functionality and transcription regulatory networks.
Now that numerous high-quality complete genome sequences are available, many efforts are focusing on the "second genomic code", namely the code that determines how the precise temporal and spatial expression of each gene in the genome is achieved. In this regard, the elucidation of transcription regulatory networks that describe combined transcriptional circuits for an organism of interest has ...
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The combinatorial cross-regulation of hundreds of sequence-specific transcription factors (TFs) defines a regulatory network that underlies cellular identity and function. Here we use genome-wide maps of in vivo DNaseI footprints to assemble an extensive core human regulatory network comprising connections among 475 sequence-specific TFs and to analyze the dynamics of these connections across 4...
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Glioblastoma multiforme (GBM) is the most common and lethal brain tumor in humans. Recent studies revealed that patterns of microRNA (miRNA) expression in GBM tissue samples are different from those in normal brain tissues, suggesting that a number of miRNAs play critical roles in the pathogenesis of GBM. However, little is yet known about which miRNAs play central roles in the pathology of GBM...
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Introduction Comprehending gene regulation has been a major endeavour in the field of bioinformatics for many years and still poses a difficult problem with a lot of uncertainties. In spite of improvements in the technologies used, e.g. high-throughput methods like ChIP-sequencing, and progress in the analysis of the driving regulators, large parts of many gene regulatory networks still remain ...
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Neph et al. (2012) (Circuitry and dynamics of human transcription factor regulatory networks. Cell, 150: 1274-1286) reported the transcription factor (TF) regulatory networks of 41 human cell types using the DNaseI footprinting technique. This provides a valuable resource for uncovering regulation principles in different human cells. In this paper, the architectures of the 41 regulatory network...
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ژورنال
عنوان ژورنال: Molecular BioSystems
سال: 2008
ISSN: 1742-206X,1742-2051
DOI: 10.1039/b715909a